Murray
Stewart
Medical Research Council Laboratory of
Molecular Biology, United Kingdom
STRUCTURAL
BIOLOGY
 New
Finding
|
This paper reports an unanticipated
interaction between the COPI complex and nuclear pore
protein Nup153 and indicates that this interaction is
important in miotic nuclear envelope breakdown. The
Zn-finger region of Nup153 inhibits nuclear envelope
breakdown in mitotic Xenopus egg extracts and appears to
function by interacting directly with COPI. Perturbing
the function of the COPI complex impairs nuclear
envelope breakdown indicating a link between this
process and cellular vesicle trafficking.
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Evaluated
29 Sep 2003 |
