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Last updated 26 September 2003
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Welcome to the Cell Biology Gateway featuring expertly selected content from the leading publications in cell biology, including Cell, Trends in Cell Biology, Current Opinion in Cell Biology and Current Biology. For a list of core cell biology-related publications from Elsevier, see Cell Biology, Developmental Biology and Molecular Biology. Sign up to receive the latest issue updates every 2 weeks. About the Gateway service.
This issue of the Cell Biology gateway features news highlights from the ELSO 2003 meeting, which is being held from 20-24 September in Dresden, Germany.

The COPI Complex Functions in Nuclear Envelope Breakdown and Is Recruited by the Nucleoporin Nup153
J. Liu et al
Developmental Cell
Based on analyses in Xenopus egg extract, this paper reports a role for COPI vesicle coatomer in nuclear envelope breakdown during mitosis, and its transfer to the ER. The nucleoporin Nup153 interacts with COPI coatomer and appears to be important for directing it to the nuclear envelope.
Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cel ...
T. Hirota et al
Hirota et al show that Aurora-A activation is required for cyclin B1-cdk1 activation at the centrosome and entry into mitosis. The LIM protein Ajuba is an interacting activator of Aurora-A and is also is required for mitosis to take place. Ajuba becomes localized to centrosomes as cells enter mitosis.
Transcription within a Functional Human Centromere
R. Saffery et al
Molecular Cell
Analaysis of a human neocentromere shows that gene transcription can take place even in the central heterochromatin region containing CENP-A and CENP-H, contrasting with previous ideas that centromeric heterochromatin would be transcriptionally silent.
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TPR Subunits of the Anaphase-Promoting Complex Mediate Binding to the Activator Protein CDH1
Hartmut C. Vodermaier et al
Current Biology
Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Int ...
H. R. Luo et al
Nuclear and territorial topography of chromosome telomeres in human lymphocytes
Jana AmrichovŠ et al
Experimental Cell Research
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Handbook of Cell Signaling
R. Bradshaw and E. Ginnis
A comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses.
Signal Transduction
B. Gomperts et al
L. Schwartz and J. Ashwell

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The churning grounds of the chimp genome
Laura Spinney
BMN Conference Reporter
Preliminary analyses of the sequenced chimp genome suggest that it contains many more duplications than the human genome. One school of thought suggests these areas of duplication might drive structural variation in the primate genome.
New virus trickery revealed
Julie Clayton
BMN Conference Reporter
Cellular traffic lights up
Julie Clayton
BMN Conference Reporter
See Also BioMedNet Conference Reporter. Daily news and profiles from ELSO 2003
Suppression of Ced-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans
T. A. Bloss et al
The worm turns to die another way: a Ced-3-independent pathway to cell death in Caenorhabditis elegans
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Blood monocytes consist of two principal subsets with distinct migratory properties
F. Geissmann
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Haprin, a novel haploid germ-cell-specific RING finger protein involved in the acrosome reaction
K. Kitamura and H. Tanaka
Journal of Biological Chemistry
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Taking the A-train: actin-based force generators and organelle targeting
Kammy L. Fehrenbacher et al
Trends in Cell Biology
The finding that there are two fundamentally different mechanisms for actin-based organelle and particle movement begs the question: how do cellular cargos employ myosin and the
BRCA1: a scaffold for p53 response?
Peter Hohenstein and Rachel H. Giles
Trends in Genetics
The authors argue that the breast cancer tumor-suppressor gene product BRCA1 might function as a molecular scaffold, assembling proteins involved in the fine-tuning of the p53 response
A Second Canon Functions and Mechanisms of β-Catenin-Independent Wnt Signaling
Michael T. Veeman et al
Developmental Cell

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