Altretamine

How do I say this name?

al-TRET-a-meen

What is this medicine used for?

Altretamine kills cancer cells.

This medicine may be called by its brand name, Hexalen^®, or by the common name, hexamethylmelamine.

How do I take this medicine?

Altretamine is taken by mouth after meals (breakfast, lunch, or dinner).

How do I store this medicine?

Store altretamine tablets or capsules at room temperature away from heat or direct light.

Are there any special things I should do while on this medicine?

Altretamine can decrease the number of white blood cells in your body, cells that usually help you fight infections. It can also decrease the number of cells in your blood that help your blood clot (platelets). Ask your doctor, nurse, or pharmacist how to reduce your risk of infection or excessive bleeding.

What if I miss a dose?

Take the medicine as soon as you remember if you skip or forget to take a dose. Skip the missed dose and stick to your regular schedule if the next dose is due in 1-2 hours. Do not increase your dose to make up for a missed dose.

What side effects are common with this medicine?

• Nausea and vomiting
• Reversible nerve problems (See symptom list below)
• Increased risk of bleeding for 4-8 weeks after therapy
• Increased risk of infection for 4-8 weeks after therapy

When should I call my doctor?

Call your doctor if you are worried about a side effect or have questions about your medical care.

Call the doctor at once if you have any of these side effects:

• Unusual tiredness or fatigue
• Skin rash, hives, or itching
• Symptoms of infection:

  Cough, hoarseness, or sore throat

  Fever above 100.5° Fahrenheit, or chills

  Pain in lower back or side

  Painful or difficult urination

  Urinating more often than normal

• Symptoms of increased bleeding:

  Black, tarry stools

  Blood in urine, stool, or vomit

  Pinpoint red spots on skin

  Unusual bruising or bleeding (nosebleeds, coughing up blood)

Call the doctor as soon as you can if you have any of these side effects:

• Symptoms of nerve problems:

  Dizziness or clumsiness
  

  Numbness or tingling in arms or legs

Are there side effects from this medicine after I finish my chemotherapy?

Altretamine may cause side effects that last for months or years after you finish chemotherapy, including decreased ability to have children. Discuss long-term effects with your doctor if you are concerned.

These written patient information materials should be used in conjunction with verbal counseling. They are not intended as the sole source of information patients receive about their chemotherapy and other medications. The adverse effects listed are important and common ones that patients might experience; every possible adverse effect is not included. Long-term adverse effects, like secondary malignancy and infertility, are discussed for those drugs whose risk is well defined.