The
nuclear pore complex is a huge macromolecular structure (120 MDa in vertebrates).
Although individual components of the nuclear pore have been identified at a
molecular level, a major challenge in the field is to understand how these components
cooperate to direct regulated, bi-directional movement of cargo. Each pore is
estimated to guide the transport of over 100 molecules per minute. Yet, despite
the “high through-put” nature of this process, transport occurs
with specificity.
