Jack Skalicky, Ph.D. - Shared Resource Director

Description

The Nuclear Magnetic Resonance (NMR) Shared Resource provides researchers with high level technical support and access to state of the art NMR software and hardware, including spectrometers operating at 400, 500, 600, 800, and 900 MHz for biomolecular structure determination as well as routine analytical NMR services for the health sciences research community. In 2004, upgrades gave the 500 and 600 MHz spectrometers state of the art capability for biomolecular NMR. A new console was installed in the 500 MHz spectrometer and the 600 MHz spectrometer, the highest field NMR spectrometer in the state of Utah, was equipped with a triple resonance cryogenic probe. The 400 MHz spectrometer is dedicated to small molecule, organic and natural products NMR applications and is exceptionally versatile and easy to use. The 800 and 900 MHz instruments are located in Colorado and are partially dedicated for the Davis and Sundquist research groups (30% of 800 and 10% of 900).

The NMR Resource owns several Sun, Silicon Graphics Inc., and LINUX workstations for offline data processing and biomolecular structure determination. These computers are located in the larger Structural Biology Computing Center (SBCC), which houses a large number of workstations and has a full time systems manager. Selected software includes CNS, CYANA, DISCOVER, DYANA, FELIX, INSIGHT, MOLMOL, NMRPIPE, SPARKY, VNMR, XEASY, and XPLOR.

The primary director of the NMR Shared Resource provides technical support for the most demanding protein and nucleic acid projects, implements multi-nuclear 2D, 3D, and 4D NMR experiments for biomolecular NMR, and assists researchers with data collection, processing, and analysis. The resource also has a full-time NMR technician responsible for running small-molecule NMR experiments on the 400 MHz and 500 MHz spectrometers. The NMR technician also trains new users of the NMR spectrometers and performs routine maintenance.

Any publication resulting from the use of this shared resource should appropriately acknowledge the N.M.R. Core and the NCI Cancer Center Support Grant P30CA042014.

In addition, for purposes of the NCI review and fulfilling the mission of the Cancer Center, please use peer-reviewed cancer related grants to pay for the services of this core facility. Contact Kris Larrabee to determine which of your grants would be appropriate to use.

Faculty Advisory Board