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We
are focused on learning what comprises the export machinery of a cell and
deciphering how this apparatus accomplishes the task of export. Having established
that Nup153 plays a critical role in specific types of RNA and protein export
(Ullman
et al, 1999), we are now defining the functional domains within Nup153
and how each of these contributes to the transport of different cargo. This
approach led us to the identification of a novel RNA binding domain within
Nup153 (Dimaano
et al., 2001, Ball
et al., 2004) and to current work aimed at deciphering how this interaction
fits into the coordinated events that lead to mRNA transport to the cytoplasm
(Ullman,
2002, Dimaano
& Ullman, 2004). |
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