The SARC Lab is a subsection of the comprehensive, interdisciplinary Sarcoma Services at Huntsman Cancer Institute and Primary Children’s Medical Center. The clinical service line serves as a major referral center for sarcomas and sarcoma related diseases from throughout the western United States and beyond. Multiple IRB approved clinical studies are underway and the SARC Lab serves as a resource for the translational ramifications of these investigations. Furthermore, with patients’ fully informed consent, all relevant surgical specimens retrieved at the time of surgery at our centers are made available to the lab for genetic profiling to elucidate a better classification schema and understanding of the pathogenesis for these rare but potentially deadly tumors.