Description

Research in the Nuclear Control Program focuses on fundamental processes in the cell nucleus that regulate the cell's biological function and go awry in the cancer cell. Researchers in the Nuclear Control Program study a variety of basic processes, including DNA replication, recombination, and repair, genetics and epigenetics, transcriptional regulation, RNA metabolism, and the role of these processes in cell growth, division, metabolism, and oncogenic transformation. Program members use multiple model systems, such as yeast, C. elegans, Drosophila, zebrafish, mouse, and patient-derived cell lines).

The Nuclear Control Program facilitates individual and cooperative research projects of representatives from many academic units on campus. It provides forums to encourage the translation of these basic research projects to more cancer-focused investigations through coordination with disease-based programs of the Cancer Center Support Grant.

The Nuclear Control Program currently receives approximately $10,350,439 per year of direct, and $13,295,078 of total research support from the NCI, other NIH institutes, the American Cancer Society and other funding agencies.   Cancer focused articles published in 2007 total 63 including 8 inter-programmatic and 1 intra-programmatic publications.

Barbara Graves, PhD
Co-leader

Stephen Lessnick, MD, PhD
Co-leader

Members