We are interested in chromosome dynamics. We want to know how genes are packaged and unpackaged, how chromatin structure regulates gene transcription, and how chromatin misregulation contributes to cancer. We purify large protein complexes that use ATP hydrolysis or acetylation to remodel chromosomal structure, and characterize their functions by reconstituting chromatin remodeling in vitro. We also apply genetic and genomic (DNA microarray) methods to understand their functions in vivo in yeast and human cells.

Developmental Biology (DBIG) Link