The primary focus of our laboratory's research is examining how cells modulate their
behavior in response to both extrinsic and intrinsic signals. This
process of signal integration has profound effects on cell migration,
morphology, and function—behaviors that, when aberrant, can
lead to cancer and other diseases. Ongoing research topics include
the mechanisms of cell migration and adhesion, how cells respond to
mechanical cues, and muscle structure and function. We take diverse approaches to study these questions, ranging from studies
of individual cells in culture to genetic-based experiments in fruit
flies, nematodes, and mice. Collectively, these studies should elucidate
the basic mechanisms underlying cell behavior and lead to a better
biological understanding of cancer and other diseases.
